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System xc- is composed of solute carrier family 3 member 2 (SLC3A2) and solute carrier family 7 member 11 (SLC7A11), and the major negative effect of system xc- on ferroptosis regulation appears to be due to its crucial role in the synthesis of the antioxidant GSH, which allows the exchange of exogenous cystine with glutamate in a 1:1 ratio
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