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2.2 Animal models Animals including mice, rats, rabbits, dogs, sheep and Zebrafish have been used for GIO modeling [33,34,35,36,37]
Majority of studies compared GLP-1RA to placebo [12, 14, 38,39,40, 44, 47, 48, 51,52,53,54,55,56,57,58,59,60,61], while others used insulin regiments and other anti-diabetic medications [41,42,43, 45,46,47, 49, 50] as the comparators
The results are presented with P values from a log-rank test
Yes, persistent or worsening fatigue despite GLP-1 treatment warrants medical review to investigate other potential causes such as anaemia, thyroid disorders, sleep apnoea, depression, or medication side effects
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