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Among the patients on polypharmacy, 18 (36%), 16 (32%), and 6 (12%) of the patients received 2, 3, and 4 psychotropic medications, respectively, as shown in Table 2

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While numerous reviews have addressed individual aspects of the gutbrain axis in PD, the present work offers a distinct conceptual contribution by integrating immunemicrobiome interactions within a unified multisystem framework that explicitly links peripheral immune dysregulation to central neuroinflammatory cascades