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Peroxidation of lipids disturbs membrane organization, causing functional loss of proteins and DNA, and are found elevated in PD patients where lipid peroxidation adducts contribute to early demise of the SNpc neurons
In this study, a carboxy-modified heptamethine cyanine (Cy-7) derivative was chosen as the fluorescence reporter due to its excellent biocompatibility and intrinsic ability to target mitochondria [39], [40], [41]
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Firstly, the full-length GLP-1 (137) was found to be catalysed by endopeptidase to the biologically active GLP-1 (737)
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