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Baseline and interval laboratory monitoring should include: fasting glucose and HbA1c (tirzepatide can cause hypoglycemia in non-diabetic subjects if caloric intake drops too low), lipase and amylase (pancreatitis risk with GLP-1 agonists), liver function tests (AST, ALT, bilirubin), and thyroid panel (TSH, free T3, free T4)
Intramuscular injections deliver B12 directly into muscle, which allows it to enter the bloodstream and bypass digestive absorption problems (NIH ODS)
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This is why oral dosages are almost always higher than injectable ones to achieve a comparable systemic effect
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