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Compared with placebo, semaglutide was shown to predict reductions in heavy drinking over time and reduce the number of cigarettes per day among smokers

In these trials, hypoglycemia was reported by 27% [69] of patients on liraglutide and 27% of patients on exenatide [70]

It could be speculated that this increased discontinuation rate vs all comparators, including GLP-1 RAs, may be possibly attributed to the severity of gastrointestinal adverse events experienced with tirzepatide 15 mg, considering that the incidence of gastrointestinal adverse events was similar between tirzepatide and GLP-1 RAs

I dont really have a timeline, Shinholster said