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The British Journal of Haematology state: The use of high dose oral cyanocobalamin is licenced for use in several countries.however the efficacy and cost-effectivenessis yet to be established. And I am stating: Vital treatment should not be restricted or stopped

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and some patients experience social or identity challenges as their body composition changes

Since in CO23RFLC the increased GSH concentration seems to be constitutive, a permanent covalent modification of GSH1 is likely to be the cause of this enhanced cellular concentration