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These associations were independent of factors including ethnicity, deprivation, microvascular complications, comorbidities, HbA1c, body mass index, and the use of other medications [23]

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NICE guidance on overweight and obesity says medicines should be used with diet and physical activity support, not as standalone treatment

The impact appears to be influenced by factors such as: Individual hormone sensitivity Starting weight and overall health status Duration of medication use Dosage levels Medical professionals emphasize that while these changes can occur, they're often temporary and may resolve as the body adjusts to the medication