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This dose was chosen based on a previous dose-escalation study and subsequent work demonstrating its efficacy to drive weight loss in a short period of time 8
it is produced by traditional organic synthesis and supplied as a crystalline solid for laboratory reconstitution in a research-appropriate solvent
This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates
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