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4.4 Weight Loss Results / Efficacy Average weight loss of 7.6% with Orlistat 8 versus ~2.0% with placebo at 24 months Over 2 years, 57% of Orlistat users maintained 5% weight loss , versus 9 37.4% in placebo recipients 4.5 Post-GLP1 Use Case 4.5 Post-GLP1 Use Case Direct studies pairing Orlistat with GLP1 tapering are limited, but emerging real-world evidence and pharmacology suggest it can help maintain weight loss: In many patients who transitioned off GLP1 therapy, Orlistat aided in preventing weight regain by continuing fat-blocking effects despite reduced appetite suppression
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