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SURMOUNT-1 trial suggests that tirzepatide may have a promising future as a therapy for obesity, HF, and non-alcoholic fatty liver disease (NAFLD) [5, 8]
One potential mechanism underlying this steatosis may be upregulation of hepatic VLDL receptor expression by PERK/eIF2 signaling, thereby enhancing hepatocyte triglyceride uptake (141)
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