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Complementary strategies include convection-enhanced delivery (CED) systems that enhance parenchymal drug distribution and chemical modifications (e.g., lipid group conjugation) to improve drug lipophilicity for BBB transit [109, 110]
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As drug manufacturing scaled up, most medications became commercially available, but compounding remained important for specific situations
Working out the role glucagon played in disease was not helped by the fact that its cellular origin remained a mystery for a number of years
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