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Hofstetter WL, Maru DM, Correa A, Shah N, Lee JH, Ajani JA, Erasmus JJ, Komaki R, Anandasabapathy S, Swisher SG

To bypass the pharmacological challenges associated with unspecific blocking of NMDA receptors, we designed a peptidedrug conjugate comprising the NMDA receptor antagonist MK-801 and a GLP-1 peptide analogue

As a consequence of heightened oxidative stress induced by Aos, the transient receptor potential melastatin 2, a Ca 2+ -permeable channel expressed on brain cells, opens [89]