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Studies have reported the expression of enzymes involved in one-carbon metabolism in ovarian granulosa cells, suggesting their potential capacity for SAM production, methylation processes, and epigenetic modulation during follicular development [254]

N Engl J Med 384(12):11131124 Osaka T, Endo M, Yamakawa M, Inoue S (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system

Despite differences in the inclusion criteria and methodology between the two studies, the findings were similar