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Use of GLP-1RA is protective and prevents bone fractures over a longer period of use in T2DM patients in a recent trial in 2020 liraglutide showed to have decreased bone resorption compared to placebo (120)

Opioids Opioids are widely prescribed to patients with cirrhosis, with reported prevalence ranging from 25 to 77% depending on the population and how use is defined [6,7,8,9]