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Figure 2 The gut microbiota constantly communicates with vital organ systems of the host, such as the brain (Dinan and Cryan, 2017), kidney (Bartochowski et al., 2022), autonomic nervous system (ANS) (Bercik et al., 2011), and immune system (Rooks and Garrett, 2016)
Nevertheless, these studies appear encouraging and more trials are underway. Although pain reduction remains important in OA, the big question and one representing a massive unmet need is whether the drugs can actually modify OA disease course
In a recent paper in The New England Journal of Medicine, physician Amanda Banks noted that the proportion of GLP-1 prescriptions written for people who were not diabetic, obese, or overweight increased from 4.5% in 2018 to 17% in 2023
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