Big impact
Tesamorelin is FDA-indicated for reducing excess abdominal fat in HIV-associated lipodystrophy, and the label states it is not indicated for weight loss management
But they can help explain why certain patients struggle more with methylation demand, homocysteine balance, detoxification pressure, oxidative stress, and nutrient depletion
We observed an initial blunted response at time points 10 ( BrAC Control = 0.037, BrAC GLP-1RA = 0.021, t(113) = 3.21, p = 0.014), 15 ( BrAC Control = 0.028, BrAC GLP-1RA = 0.013, t(113) = 2.98, p = 0.028) and 20 min (BrAC Control = 0.037, BrAC GLP-1RA = 0.017, t(113) = 3.87, p = 0.001) in the GLP-1RA group as compared to the control group