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Recent research suggests that SCFAs, exercise-induced lactate, and specific pro-resolving lipid mediators (resolvins, maresins) might direct microglia and astrocytes to these protective phenotypes [140, 141]

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To identify IGF-1-mediated miRNA regulatory networks that cause temozolomide (TMZ) to be insensitive to glioblastoma multiforme treatment, on the basis of comprehensive analysis of multiple databases and in vitro experiments, Chen et al (104) confirmed that IGF-1 upregulated miR-513a-5p signaling reduced the sensitivity of glioma cells to TMZ by inhibiting the NEDD4L-inactivated Wnt/-catenin pathway

Polidoro G et al