A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)
Brand-name Wegovy at cash-pay list price runs roughly $1,000$1,350/month before insurance
Research shows that it may help protect the digestive tract (gi tract), including the gastrointestinal lining, from damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs), helping to maintain gut health and function
Int J Mol Sci 22:11453 Hao Y, Zhao L, Zhao JY, Han X, Zhou X (2023) Unveiling the potential of mitochondrial dynamics as a therapeutic strategy for acute kidney injury