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Source: Evaluate Pharma, World Obesity Federation, Putnam Analysis Q2, 2025 Unmet Needs and Potential Differentiation Levers Despite extraordinary promise, there are still unmet needs that biopharma companies can target to address: GI Tolerability The most common GI adverse events (nausea, vomiting, and diarrhea) often lead to therapy discontinuation

If additional glycemic control is needed Ozempic may be further titrated up to 1 mg subcutaneously once weekly after 4 weeks at the 0.5 mg dose

Liu, H., et al

Summary Ipamorelin, a synthetic peptide, is a selective secretagogue that triggers the release of growth hormone with minimal to no effect on other hormones