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Ending slightly early is better than running out mid-protocol next time
ICP22-mediated inhibition of apoptosis likely involves p53, a cellular transcription factor that controls apoptosis by activating Bax or inhibiting Bcl-2, and that has been shown to be antagonized by ICP22 which promotes cell survival (Figure 2A
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A number of issues tripped up the Montrealbased biotech, according to its press release announcing the Complete Response Letter, including chemistry, manufacturing and controls issues
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