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Barton, the discussant, took a cautionary view, saying that there are some things to consider before going out and telling patients to consider acetyl-carnitine for their peripheral neuropathy. It was unclear from the results reported whether the two treatment groups were well balanced and what criteria were used to define improvement for the secondary outcomes, she noted

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Participants lost weight during the first 65 weeks of treatment and then maintained their weight loss for the remainder of the trial

Acute and prolonged effects of insulin-induced hypoglycemia on the pituitary-thyroid axis in humans