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doi: 10.1016/j.ijbiomac.2021.08.054 90 ShadeKCConroyMEWashburnNKitaokaMHuynhDJLapriseEet al

Action of glutamic acid and glutathione analogues on the Hydra glutathione-receptor

499 GPX4 is significantly decreased in the hearts of patients with diabetes and hyperglycemia, indicating that GPX4 may play an antioxidant role in diabetic cardiomyopathy

Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the -ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety