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Both doses were safe and well tolerated, but the high-dose regimen achieved markedly higher plasma concentrations and produced a faster, greater reduction in SOFA scores and inflammatory biomarkers (CRP and procalcitonin), while preventing thrombomodulin elevation (Fowler et al., 2014)
The effect strengthens with each dose escalation, with maximum appetite control typically reached at the 2.4mg maintenance dose around week 17
For example, if you're unsure whether you received the full dose, do not administer additional medication without medical advice
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