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According to the American Diabetes Association Standards of Care, GLP-1 receptor agonists produce weight loss through multiple mechanisms including central appetite regulation and delayed gastric emptying, beyond gastrointestinal side effects alone
Others might require maintenance low-dose retatrutide after goal weight
Importantly, GLP-1 promotes insulin secretion in a glucose-dependent manner
doi: 10.1089/thy.2015.0061 66 MarcocciCWattTAlteaMARasmussenAKFeldt-RasmussenUOrgiazziJet al
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