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Whether similar trigger-wave dynamics can be sustained in complex three-dimensional tissues, where geometry, extracellular matrix, and heterogeneous antioxidant buffering may substantially alter propagation behavior, remains an important open question and a critical test of the models physiological generalizability

J Eur Acad Dermatol Venereol 38(4):710718 Acknowledgements Not applicable

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Neuropathology of variants of progressive supranuclear palsy