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Glaucoma is one such disease, characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy, leading to progressive and permanent vision loss
The source in this case may be pyruvate from glycolysis, beta-oxidation of fatty acids, or proline (or possibly glutamine), which is converted in the mitochondria to glutamate and alpha-ketoglutarate, which may be converted in one direction to isocitrate and in the other to malate, thus serving as a source for NADPH formation
L-Carnitine Nereden Alnr
Rebouche CJ, Engel AG: Carnitine metabolism and deficiency syndromes
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