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Concurrent mitochondrial dysfunction includes reduced respiratory chain activity, disrupted oxidative phosphorylation, and increased HO release, though these effects are partially mitigated by PARK2-mediated preservation of mitochondrial Ca 2+ retention capacity and NF-B-driven OPA1 expression (Piquereau et al., 2013)
In my practice, I view it as a complementary, not competitive, ingredient: a reasonable addition for women who cannot tolerate retinoids, or as part of a layered approach for those who can
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