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& Barzilai, N
The GLP-1 and GIP components enhance insulin secretion and sensitivity, while the glucagon component, somewhat paradoxically, does not worsen blood sugar control because its glucose-raising effects are offset by the dominant insulin-enhancing effects of the other two pathways
Specification and emulation of the reference trial including our expansion studies are stated in the Supplementary Information, following the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline (Supplementary Tables 2729) 42
