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The S4 category covering hormone and metabolic modulators is also relevant to GLP-1, GIP, and glucagon receptor agonists generally

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265,266 Disorders of metabolic homeostasis in obese individuals promote several pathological processes, such as type 2 diabetes, insulin resistance, and an increased incidence of various cancers

some authors proposed it for preterm babies affected by necrotizing enterocolitis 116 , for hemolytic hyperbilirubinemia-induced oxidative brain damage 117 , intrauterine fetal growth retardation 118,119,120,121 , chronic lung disease (CLD), and periventricular leukomalacia