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CTP fusion became an established half-life-extension strategy alongside PEGylation, albumin binding and Fc fusion, and it produced at least one licensed long-acting gonadotropin built by attaching the hCG beta CTP to a different beta subunit

Product selection requires attention to formulation details, not just concentration percentages

Adults over the age of 65 Due to a number of common issues associated with ageing, including the reduced production of stomach acid, people over the age of 65 may be more prone to a B12 deficiency

Long-term safety with chronic use hasn't been established in rigorous clinical trials