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Thus, GS activity appears to be mainly controlled by substrate availability

In the context of GLP-1R agonists, GLP-1-expressing NTS neurons send projections to serotonergic DRN neurons, and chemical depletion of serotonin as well as blockade of central 5-HT 2A receptors, but not 5-HT 2C receptors, prevents the inhibitory effects of chronic central exendin-4 on food intake and body weight in rats [109]

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Additionally, GLP-1 drugs, through their influence on hormonal regulation, might indirectly impact the delicate hormonal balance within the body