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In GPX5-gene KO mice, sperm DNA damage is significantly increased, while an 8-weeks pretreatment of GPX5 KO mice using antioxidants completely protects sperm DNA from oxidative stress damage ( 2.6 GPX6 Glutathione peroxidase 6 (GPX6), also known as olfactory organ glutathione peroxidase ( It is believed that GPX6 is mainly expressed in embryonic and olfactory organ epithelial cells, and may be involved in the transmission and degradation of odor-related signals
Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)
What if, however, there was a solution to this conundrum
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