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MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

Stability studies of pharmaceutical dispersed system The Pharma Innovation Journal

However, in a subanalysis of participants with low vitamin B 12 status at baseline (n= 101), the B-vitamin supplementation slowed the decline in bone mineral density (total hip and femoral neck but not lumbar spine) (116)

We also explored several other known regulators of PGC1 activity that are altered in response to 5FU treatment in HCT116, including NRF2, reactive oxygen species and PPAR, but none of these prevented PGC1-driven increases in mitochondrial mass