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Supplementary Figures Acknowledgements We would like to thank the Scientific Technology Platforms (STPs) at The Francis Crick Institute, particularly High Throughput Screening for their collaboration to develop the arrayed CRISPR-Cas9 screen, and the Biological Research Facility for breeding and maintenance of mouse lines

Recovery and Sleep: CJC-1295/Ipamorelin and Tesamorelin CJC-1295/Ipamorelin is a growth-hormone-axis combination used to support systemic recovery and deeper sleep, which matters because collagen turnover and tissue repair happen largely during deep sleep

Comprehensive Health Benefits Beyond physical fitness, L-carnitine injections have been associated with cardiovascular benefits, supporting a healthier heart and improved blood flow

Sleep and recovery improvements often appear within the first few weeks, while body composition and energy changes build over 4 to 8 weeks, with the most significant results typically around the 3 to 6 month mark