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The extensive contact area between peptide ligands and the GLP-1 receptor, spanning both the ECD and TMD and involving dozens of intermolecular contacts across a surface area exceeding 1,000 square angstroms, seemed to require the structural complexity that only a peptide could provide
The treatment is most commonly used in specific zones that resist diet and exercise, making it appealing to people near their ideal body weight who struggle with localized fat deposits
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doi: 10.1172/JCI23394 61 ChoyEHDe BenedettiFTakeuchiTHashizumeMJohnMRKishimotoT
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