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A meta-analysis of 80 000 patients found GLP-1 RAs were not associated with an increased risk of optic nerve/vision-threatening events [11], and a recent clinical trial of people taking the highest dose of semaglutide demonstrated excellent safety, increased muscle strength and an increased ratio of lean mass relative to total body mass in people taking semaglutide [12]
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Currently, there are few ongoing clinical trials with peptide polyagonists in NASH, including tirzepatide (SYNERGY-NASH
In: Bandi V, Shanker AK, Shanker C, Mandapaka M (eds) Crop stress and its management: perspectives and strategies
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