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Starting with a low dose and gradually increasing it under a doctors supervision can help
In STEP 1 (NEJM 2021), FDA-approved semaglutide 2.4 mg with lifestyle support produced a mean 14.9% body weight reduction at 68 weeks versus 2.4% with placebo
In rodents, Mournaro medications and medications that work like Mounjaro, caused thyroid tumors including thyroid cancer
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