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2 Among these, cold exposure and fasting are well-studied paradigms that necessitate metabolic flexibility, prioritizing fatty acid oxidation over glucose catabolism to sustain systemic energy balance while sparing glucose for obligate tissues such as the brain
In contrast, long-acting GLP-1RA has a less pronounced effect on gastric emptying over time due to tachyphylaxis [72] but yields more significant and consistent weight loss [71]
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Deficiency leads to methylmalonic acid accumulation, which can cause neurological damage over time
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