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Pharmaceuticals 11 , 51 (2018)
An increase of 6.5 fold and ~2 fold in brain delivery of methylprednisolone [43] and the opioid peptide [44] respectively were reported in rat brain when compared with a control where a free drug was used
Treating cells with L-buthionine sulfoximine (BSO), an inhibitor that blocks the synthesis of GSH, renders neuronal SH-SY5Y cells expressing mutant valosin-containing protein (VCP) R487H more susceptible to oxidative stress (Hirano et al., 2015) and increases mutant SOD1 toxicity (Alvarez-Zaldiernas et al., 2016
Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties
