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A placebo-controlled study of 72 patients with type 2 diabetes found that oral administration of lipoic acid at doses of 600 mg/day, 1,200 mg/day or 1,800 mg/day improved insulin sensitivity by 25% after four weeks of treatment (58)

Conversely, it may enhance the renal excretion of some drugs, such as amphetamines and certain tricyclic antidepressants, by acidifying the urine

The table below assumes 2.4 mg weekly maintenance for each compound

The GIP component appears to enhance insulin sensitivity in fat tissue, improve lipid metabolism, and potentially increase energy expenditure in ways that pure GLP-1 agonists cannot match