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A cofactor is something that is required for an enzyme to catalyze a chemical reaction
Also, although the body of literature has little to say about combining NMN and NR, these precursors different entry points in the salvage pathway suggest that taking them together may help you achieve the highest possible NAD+ boost
There is some preliminary evidence that saunas and cold plunges can raise NAD+ as well, but these tools may not be for everyone, and research is still in very early stages
Glutathione is less available for other essential tasks, like skin repair and biological defence
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