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Anecdotally, I can say this has worked for some of my patients.

Common side effects including nausea, vomiting, diarrhoea, and reduced appetite can significantly impact energy levels, particularly during dose escalation

GLP-1 neurons in the nucleus tractus solitarius widely project to the central nervous system, including the hypothalamus (paraventricular nucleus, supraoptic nucleus, arcuate nucleus, and hypothalamic dorsomedial nucleus), brainstem (parabrachial nucleus, reticular formation, dorsal vagal nucleus), thalamus, and intermedio-lateral cell column

When performed by trained professionals using FDA-approved products, these treatments are generally considered safe