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The effect is usually indirect, caused by fatigue from caloric restriction, GI discomfort, or hormonal shifts from rapid weight loss

Your genes can impact how you respond to a GLP-1 In a study published in Genome Medicine , researchers found that about 10 percent of people carry certain variants of what's known as the PAM gene, and those individuals had a weaker blood sugar response to GLP-1based drugs compared to non-carriers

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PMCID: PMC8138308 Morlino S, Micale L, Ritelli M, Rohrbach M, Zoppi N, Vandersteen A, Mackay S, Agolini E, Cocciadiferro D, Sasaki E, Madeo A, Ferraris A, Reardon W, Di Rocco M, Novelli A, Grammatico P, Malfait F, Mazza T, Hakim A, Giunta C, Colombi M, Castori M