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These findings are clinically relevant as central adiposity, particularly visceral fat, is strongly linked to the pathogenesis of insulin resistance, chronic inflammation, and cardiovascular disease

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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )