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'Then it's just a matter of scientists looking in the right place
If the Sigma GST FhGST-S1 is then pro-actively released into the host gastro-intestinal environment via EVs then the presence of the disulfide bond would stabilise the released protein in its non-reducing host environment
For instance, in individuals with melanocortin receptor 4 (MC4R) deficiency (a genetic model of obesity), heightened activity in the ventral and dorsal striatum has been observed in response to palatable foods compared to individuals without MC4R mutations
doi: 10.1038/mp.2016.77 73 JuanC
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