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PLoS One 9 , e98792 (2014)

These include: Enhanced glucose-dependent insulin secretion Suppressed glucagon secretion Slowed gastric emptying Increased satiety via central hypothalamic action This results in both glycaemic improvement and clinically meaningful weight loss

Chronic mild stress influences nerve growth factor through a matrix metalloproteinase-dependent mechanism

The superior clinical efficacy of liraglutide as monotherapy and dual- or triple-drug combination therapy compared to placebo or active comparators (e.g., a sulfonylurea, rosiglitazone, insulin glargine, and exenatide twice daily injection) was demonstrated by the Liraglutide Effect and Action in Diabetes (LEAD) study program [59]