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Patients should also disclose all medications and supplements currently being taken, including prescription, over-the-counter drugs, vitamins, and herbal remedies, to avoid unexpected interactions and optimize therapeutic efficacy

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Increased superoxide production was observed in all layers of the vascular wall, namely the endothelium, media and adventitia, 14 and may also increase vasoconstrictor tone via stimulation of the expression of endothelin-1 in the smooth muscle and endothelial cell layer

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