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Humana Press: Totowa, NJ, 1997

Gastrointestinal inflammation seen in ASD increases the risk of nutrient deficiency [94]

(4) More specifically, researchers posit that when Melanotan I activates MC1R, cAMP is produced, and it activates microphthalmia transcription factor (MITF) expression, which induces the expression of enzymes for eumelanin production