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Options at plateau include maintaining the current dose to prevent regain (the STEP 4 trial showed rapid weight regain after discontinuation), adding structured exercise to increase energy expenditure, reviewing dietary quality rather than just quantity, and in some cases, considering a temporary dose increase if prescribed by a provider
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Intriguingly, GSH recovered by 12 weeks to control levels, without affecting the extent of mucosal damage
The employer component follows Quebecs mandatory drug coverage model : applied here it would require employer drug plans that already cover obesity-related conditions hypertension, type 2 diabetes, cardiovascular disease to also cover Health Canada-approved GLP-1s for obesity, with no time cap
